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SPEARHEAD solutions slowed down antibiotic resistance through the development of a novel risk prediction model and rapid diagnostics for doctors that allow personalized care, while also engaging patients and citizens for better treatment outcomes. SPEARHEAD solutions combined innovation in clinical care with citizen engagement to address antimicrobial resistance. The project developed a novel risk prediction model and rapid diagnostic tools to support personalised treatment, while generating evidence to guide cost-effective AMR solutions and inform policy and investment decisions.